The Company
Leading the quest for drugs against aging
Our Approach
Anti-aging therapeutics have long been a topic for fiction writers rather than pharmacologists. The situation has radically changed today, with aging treatment turning into a more and more realistic opportunity being explored by several recently launched companies ( read our white paper CONFRONTING THE LAW OF NATURE ). Everon’s approach is unique and comprehensive. Its major conceptual and technological cornerstones are summarized below:
- Aging is a physiologically programmed process that is pre-determined at the DNA level. Because of that, the onset of systemic physiological decline (frailty) occurs at a genetically defined age that varies across mammalian species.
- The accumulation of aging-associated frailty can occur independently of the acquisition of age-related diseases; however, the risk of the latter is increased in a frail organism and can accelerate aging.
- Molecular genetic mechanism identified by Everon researchers in partnership with Roswell Park Cancer Institute scientists serves as a program underlying aging. This mechanism explains the gradual accumulation of cellular and extracellular waste products that poison the microenvironment of aging tissues.
- The gradual accumulation of waste products with age exhausts the “waste removal” branches of the immune system; this in turn leads to its malfunction and to the development of sterile chronic inflammation.
- Aging can be quantitatively measured. Everon has implemented three robust diagnostic tools for detecting changes in physiological age; these tools are essential for assessing the efficacy of anti-aging drugs:
- Frailty Index (FI) as a measure of age-related malfunction of all body components;
- A proprietary bioinformatics tool for the detection of aging biomarkers in DNA samples from somatic cells of human and mouse;
- An optical device combined with subcutaneous diagnostic assay for the functional assessment of objective biological age.
The Team
Publications
Papers
David Frescas et al (2017) Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent (http://www.tandfonline.com/doi/full/10.1080/15384101.2017.1339850)
Brandon Hall et al (2017) p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli (http://www.aging-us.com/article/101268/text) or (https://doi.org/10.18632/aging.101268)
M. Antoch et al (2017) Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice (http://www.aging-us.com/article/101206)
D. Frescas et al (2017) Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody (http://www.pnas.org/content/early/2017/02/09/1614661114.short)
B. Hall et al (2016) Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells (http://www.aging-us.com/article/100991)
Presentations
- A. Gudkov’s Lecture: Small molecule that extends life- and health-span in a mouse model of chronological aging: molecular mechanisms and cellular targets (VIDEO)
- B. Hall et al (POSTER) p16(Ink4a) and Senescence-Associated β-galactosidase (SABG) as Markers of Reversible Physiological Response in Macrophages
- D. Frescas et al (POSTER) Senescent cells expose and secrete a novel oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody
- M. Antoch et al (POSTER) Defining biological age of individual mice by creating the Frailty Index
- E. Leonova et al (POSTER) Systemic DNA damage stays indefinitely dormant or turns into accelerated aging depending on life conditions
- I. Gitlin et al (POSTER) Is inflammaging essential for mouse aging?
Cellular Senescence: From Molecular Mechanisms to Therapeutic Opportunities; Weizmann Institute, Rehovot, Israel, July 3-6, 2016
- A.Gudkov’s Lecture: Biological sense of senescent cells (VIDEO)
Andrei Gudkov`s TEDx talk on May 28, 2017: Can we stop aging? (VIDEO)

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Contact Us
640 Ellicott St., Suite 444
Buffalo, NY 14203
Phone: 716.858.3055
Fax: 716.858.3044
Email: info@everonbio.com
Web: www.everonbio.com